Candida Albicans Nucleic Acid

Candida species is the largest normal fungal flora in human body, which is widely present in the respiratory tract, digestive tract, genitourinary tract and other organs that communicate with the outside world. It is not pathogenic generally and belongs to conditional pathogenic bacteria. Due to the massive application of immunosuppressive agents, development of tumor radiotherapy, chemotherapy, invasive treatment, and organ transplantation, and the widespread application of a large number of broad-spectrum antibiotics, the normal flora becomes imbalanced, leading to Candida infections in the genitourinary tract and respiratory tract.

Candida infection in the genitourinary tract can cause women to suffer from candidal vulvitis and vaginitis, and cause men to suffer from candidal balanitis, acroposthitis and prostatitis, which seriously affect the life and work of patients. The incidence rate of genital tract candidiasis is increasing year by year. Among them, female genital tract candida infections account for about 36%, and males account for about 9%, and Candida albicans (CA) infections are the main ones, accounting for about 80%.  

Fungal infection typical of Candida albicans infection is an important cause of death from nosocomial infections. Among critical patients in ICU, Candida albicans infection accounts for about 40%. Among all visceral fungal infections, pulmonary fungal infections are the most and they are increasing year by year. Early diagnosis and identification of pulmonary fungal infections has important clinical significance.

The current clinical reports of Candida albicans genotypes mainly include type A, type B, and type C, and such three genotypes account for over 90%. Accurate diagnosis of Candida albicans infection can provide evidence for the diagnosis and treatment of candidal vulvitis and vaginitis, male candidal balanitis, acroposthitis and prostatitis, and respiratory tract Candida albicans infection.