Human Leukocyte Antigen B27 Nucleic Acid Detection Kit

Short Description:

This kit is used for qualitative detection of the DNA in the human leukocyte antigen subtypes HLA-B*2702, HLA-B*2704 and HLA-B*2705.


Product Detail

Product Tags

Product name

HWTS-GE011 Human Leukocyte Antigen B27 Nucleic Acid Detection Kit (Fluorescence PCR)

Epidemiology

Ankylosing spondylitis (AS) is a chronic progressive inflammatory disease that mainly invades the spine and may involve the sacroiliac joints and surrounding joints to varying degrees. It has been revealed that AS exhibits obvious familial aggregation and is closely related to human leukocyte antigen HLA-B27. In humans, more than 70 kinds of HLA-B27 subtypes have been discovered and identified, and of them, HLA-B*2702, HLA-B*2704 and HLA-B*2705 are the most common subtypes related to the disease. In China, Singapore, Japan and Taiwan district of China, the most common subtype of HLA-B27 is HLA-B*2704, accounting for approximately 54%, followed by HLA-B*2705, which accounts for approximately 41%. This kit can detect the DNA in subtypes HLA-B*2702, HLA-B*2704 and HLA-B*2705, but does not differentiate them from each other.

Channel

FAM HLA-B27
ROX

Internal Control

Technical Parameters

Storage

Liquid: ≤-18℃ 

Shelf-life Liquid: 18 months
Specimen Type whole blood samples
Ct ≤40
CV ≤5.0%
LoD 1ng/μL
Specificity The test results obtained by this kit will not be affected by hemoglobin (<800g/L), bilirubin (<700μmol/L), and blood lipids/ triglycerides (<7mmol/L) in blood.
Applicable Instruments Applied Biosystems 7500 Real-Time PCR Systems

Applied Biosystems StepOne Real-Time PCR Systems

LightCycler®480 Real-Time PCR system

Agilent-Stratagene Mx3000P Q-PCR System


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