Influenza B Virus Nucleic Acid

Influenza virus, a representative species of Orthomyxoviridae, is a pathogen that seriously threatens human health and can widely infect hosts. Seasonal influenza epidemics infect about 600 million people worldwide and cause 250,000 to 500,000 deaths every year , of which influenza B virus is one of the main causes^[1]. Influenza B virus, also known as IVB, is a single-stranded negative-stranded RNA. According to the nucleotide sequence of its antigenic characteristic HA1 region, it can be divided into two major lineages, the representative strains are B/Yamagata/16/88 and B/Victoria /2/87(5)^[2]. Influenza B virus generally has strong host specificity. It has been found that IVB can only infect humans and seals, and generally does not cause a worldwide pandemic, but it can cause regional seasonal epidemics ^[3]. Influenza B virus can be transmitted through various routes such as the digestive tract, respiratory tract, skin damage and conjunctiva. The symptoms are mainly high fever, cough, runny nose, myalgia, etc. Most of them are accompanied by severe pneumonia, severe heart attack. In severe cases, heart, kidney and other organ failure leads to death, and the fatality rate is very high ^[4]. Therefore, there is an urgent need for a simple, accurate and rapid method for detecting influenza B virus, which can provide guidance for clinical medication and diagnosis.