Chronic myelogenousleukemia (CML) is a malignant clonal disease of hematopoietic stem cells. More than 95% of CML patients carry the Philadelphia chromosome (Ph) in their blood cells. And the BCR-ABL fusion gene is formed by a translocation between the ABL proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) on the long arm of chromosome 9 (9q34) and the breakpoint cluster region (BCR) gene on the long arm of chromosome 22 (22q11). Its fusion protein encoded by this gene has tyrosine kinase (TK) activity, and activates its downstream signaling pathways (such as RAS, PI3K, and JAK/STAT) to promote cell division and inhibit cell apoptosis, making cells proliferate malignantly, and thereby causing the occurrence of CML.
BCR-ABL fusion gene, which is important in the development of CML, serves as a key diagnostic marker of CML. Its detection helps to monitor patient’s response to tyrosine kinase inhibitors (TKIs) and predicts leukemia recurrence, which is essential to effective CML patient management.
Human BCR-ABL Fusion Gene Mutation Detection Kit from Macro & Micro-Test for qualitatively detection of the BCR-ABL in CML patients, assists CML diagnosis and guides targeted clinical treatments to optimize therapeutic strategies for effective patient management.BCR-ABL fusion gene, which is important in the development of CML, serves as a key diagnostic marker of CML. Its detection helps to monitor patient’s response to tyrosine kinase inhibitors (TKIs) and predicts leukemia recurrence, which is essential to effective CML patient management.
Human BCR-ABL Fusion Gene Mutation Detection Kit from Macro & Micro-Test for qualitatively detection of the BCR-ABL in CML patients, assists CML diagnosis and guides targeted clinical treatments to optimize therapeutic strategies for effective patient management.
Comprehensive Detection: Simultaneous detection for 3 common fusion genes (P210, P190, P230) for broad coverage and prevention from missed cases;
High Sensitivity: The liquid version detects fusion genes with LoD of 1000 copies/mL, and the lyophilized version of 500 copies/mL;
Excellent Accuracy: Internal control and UNG enzyme to prevent false positives & negatives;
Easy Operation and Efficiency: Closed-tube operation, free of products post-processing, and detection within 60 minutes for objective and reliable results;
More Options：Liquid and lyophilized versions for clients' options;
Wide Compatibility: Compatible with most PCR systems for wide lab accessibility.
Comprehensive Detection: Simultaneous detection for 3 common fusion genes (P210, P190, P230) for broad coverage and prevention from missed cases;
High Sensitivity: The liquid version detects fusion genes with LoD of 1000 copies/mL, and the lyophilized version of 500 copies/mL;
Excellent Accuracy: Internal control and UNG enzyme to prevent false positives & negatives;
Easy Operation and Efficiency: Closed-tube operation, free of products post-processing, and detection within 60 minutes for objective and reliable results;
More Options：Liquid and lyophilized versions for clients' options;
Wide Compatibility: Compatible with most PCR systems for wide lab accessibility.
Post time: May-16-2024